The Science Behind Our 3-Step Hair Activation Routine

Medically reviewedby Edna Skopljak M.D.
WrittenbyLiza Schermann
Last updated

We dissected all the scientific studies so you don’t have to.

Our mission is to give you the confidence of having strong, healthy, voluminous hair. Using our expertly-curated Bio-Pilixin formula®, we bring you the complete solution against hair loss.

Check out the science behind the potent ingredients used in our Bio-Pilixin® Routine-series for both men and women. This 3-step haircare treatment consists of a hair strength shampoo, hair recovery conditioner, and Bio-Pixilin Activation serum.

You may read further information on the rest of our naturally-derived ingredients here.

But first, let’s dive into the active ingredients.




Explore a range of powerful ingredients in the Bio-Pilixin® Routine-series, a comprehensive 3-step haircare system designed to prevent hair loss and enhance hair health.

In this overview, we delve into the key components, such as Curcuma Longa Callus Conditioned Media, Aloe Barbadensis Leaf Extract, Amaranthus Caudatus Seed Extract, Biotin, Brassica Campestris/Aleurites Fordi Oil Copolymer, Crambe Abyssinica Seed Oil Phytosterol Esters, Hydrolyzed Quinoa, Niacinamide, Sodium PCA, Arginine with Amino Acids Mix, Zinc PCA, and Vanillyl Butyl Ether.

These ingredients have undergone clinical testing and offer a range of benefits, from reducing hair loss to promoting increased hair density and enhancing hair strength, making the Bio-Pilixin® Routine-series a potent solution for maintaining strong and healthy hair.


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Curcuma Longa Callus Conditioned Media

Function: Hair bulb caring, promoting the hair follicle

Curcuma Longa Callus Conditioned Media is a moisturizing agent common in skincare and cosmetics. This ingredient stimulates and promotes hair follicle growth to create healthier, new hair.

Clinical Studies

To study the ingredient’s effects on hair, a test was made including 40 volunteers, 1% dosage, and 1 application/day on the scalp.


  • Up to 89% hair loss reduction after 150 days
  • Up to 52% hair density increase after 150 days

Hair and Scalp Benefits

  • Maintain strong and vital hair
  • Reduces hair loss
  • Increases hair volume

Aloe Barbadensis Leaf Extract

Function: emollient, humectant

Aloe vera, dubbed as a “wonder plant”, has many uses obtained from the gel of the plant’s leaves. Our skin absorbs Aloe vera up to four times faster than water. It helps open up our pores, making it easier to receive moisture and nutrients from the plants.

It is also used as a treatment for Seborrheic dermatitis (SD). SD is a skin condition that frequently develops on the face and scalp. It causes a pinkish-red rash and crusty, yellow-white scales on the surface of the skin, which may also be swollen and greasy.

Hair and Scalp Benefits

  • Reduces itchiness, scaliness, and the size of the area affected by SD
  • Promotes increased hair density (as some cases of SD lead to hair loss)
  • Contributes to a healthy scalp
  • Stimulates blood circulation and improve the delivery of oxygen and nutrition to hair follicles

Amaranthus Caudatus Seed Extract

Function: Moisturizing agent, Protective agent

From the Amaranth plant, the seed extract is a popular health food thanks to its great nutritional benefits and high protein content. It enhances the hair’s overall structural integrity.

Hair and Scalp Benefits

  • Increases the diameter of individual hair fibres from the inside out (for fuller, thicker and healthier looking hair)
  • Reduces friction between the strands allowing for more hair movement
  • Reduces the risk of mechanical damage


Function: Hair-conditioning agent

Biotin (also known as vitamin B7 or vitamin H) is a water-soluble vitamin that serves to improve your body’s keratin (a basic protein that makes up your hair, skin, and nails) infrastructure. Research on its effects remains sparse, however.

Brassica Campestris/Aleurites Fordi Oil Copolymer

Function: Film-forming ingredient

Brassica Campestris/Aleurites Fordi Oil Copolymer is a biodegradable, botanical-based polymer made from sustainable tung (China wood) and rapeseed oils. It forms a protective film on your skin and hair for even coverage.

Clinical Studies

Study 1: Improvements in Heat Protection at 450°F

Study 2: 24-hour Frizz Control for Flat Ironed Hair

Study 3: 24-hour Frizz Control for Naturally Dried Hair


Studies concluded produced the following results:

Study 1:

  • Significant protection from heat damage
  • Strengthened against hair breakage
  • Smoother & healthier looking cuticles (than the placebo and silicone)

Study 2:

  • Controlled frizz for 24 hours
  • Smoother, more defined hair

Study 3:

  • Improved style & definition in air-dried hair while
  • Frizz protection for 24 hours
  • Efficient heat protection and hair strengthening

Hair and Scalp Benefits

  • Strengthens and improves shine for healthier hair
  • Significantly prevents heat damage that causes decreased elasticity making hair more resilient

Crambe Abyssinica Seed Oil Phytosterol Esters

Function: Hair conditioning

The Crambe abyssinica is an oilseed crop belonging to the Brassicaceae family. It is an excellent moisturizing agent that acts as a comforting and protective film on your skin.

Hair and Scalp Benefits

  • Conditions and strengthens hair
  • Enhances hair shine
  • Improves hair elasticity
  • Increases hair volume by forming a film

    Hydrolyzed Quinoa

    Function: Hair repair

    Quinoa protein is a vegetable protein known for its ability to greatly assist in the repair, protection, and conditioning of hair.

    Clinical Studies

    To study the ingredient’s effects on hair repair, six double-bleached Caucasian hair swatches were prepared by cleansing with a 10% sodium lauryl ether sulfate (SLES) solution and rinse.

    Treated swatches were then submitted to a cycle of five applications of a 1% aqueous Quinoa Pro EX solution with a 10% SLES wash after each treatment. The control swatches were washed and dried only.


    • Improves hair damage after first treatment by 16%
    • 32% improvement after five treatments

    Hair and Scalp Benefits

    • Improves the condition of dry, damaged or treated hair
    • Improves hair gloss
    • Ameliorate the ability of the hair to be combed


    Function: Smoothing

    Niacinamide is the physiological form of Niacin (vitamin B3). When used as a cream, this ingredient helps treat certain skin conditions, including acne and eczema.

    Clinical Studies

    To study the ingredient’s effects as a treatment for female pattern alopecia, the pilot study examined the effect of topical application of two niacin derivatives, octyl nicotinate, and tetradecyl nicotinate, on hair fullness in female alopecia.


    • Increased density of active hair follicles or the quality of the existing hair shafts, leading to a significant increase in hair fullness

    Sodium PCA. PCA and Arginine in combination with Amino Acids Mix

    Function: Damage Care

    Clinical Studies

    A study was conducted on the effects of arginine on hair damage via oxidative colouring process.


    • Reduces hair damage
    • Improves hair colour retention

    Hair and Scalp Benefits

    • Improves hair strength and hair shine
    • Improves the dry feel of hair (combability, smoothness, and silky feel)
    • Improves the wet feel of hair (combability and smoothness)
    • Improves colour retention of dyed hair

    Zinc PCA

    Function: Humectant

    Zinc is an essential mineral that helps the immune system fight off invading bacteria and viruses. When used in creams, it has shown significant results on anti-ageing properties and soothing properties.

    Clinical Studies

    To study the ingredient’s effects as a treatment for hair loss, a topical zinc pyrithione 1% solution has been used on those with androgenic alopecia.


    • Considerable improvement in hair density

    Hair and Scalp Benefits

    • Efficient hair density due to amino acid and blood flow-promoting agents

    Vanillyl Butyl Ether

    Function: Hair conditioning

    Vanillyl Butyl Ether is an active ingredient often present in cosmetics and personal care products as a fragrance ingredient, oral care agent, hair conditioning agent, and warming or cooling agent.

    Clinical Studies

    The raw material was studied to see its effects on hair.


    • Improves blood flow (for better nutrient delivery to hair roots)
    • Promotes increased hair density
    • Reduces inflammation related to hair loss

    Hair and Scalp Benefits

    • Enhances local blood cell flow
    • Increases hair density
    • Revitalizes scalp
    • Strengthens hair
    • Prevents hair loss

    Hair Activation Routine | For Men
    Hair Activation Routine | For Men
    Formulated to combat shedding & signs of balding

    Hair Activation Routine | For Women
    Hair Activation Routine | For Women
    Formulated to combat thinning hair & visible scalp

    Bio-Pilixin® Activation Serum | For Men
    Bio-Pilixin® Activation Serum | For Men
    Drug-free & clinically tested

    Bio-Pilixin® Activation Serum | For Women
    Bio-Pilixin® Activation Serum | For Women
    Drug-free & clinically tested



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